Abstract
The formation of blood cells is a tightly regulated process initiated from a rare population of multipotent hematopoietic stem cells (HSCs). Subsequent differentiation events proceed in a hierarchical manner with the generation of intermediate progenitors in which alternative lineage potentials become gradually restricted. A deeper understanding of these events is crucial not only when striving to understand normal blood cell formation, but also for the understanding of diseases such as leukemia, where inappropriate differentiation is a defining feature.
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