Critical care pharmacotherapy: issues and approaches.

Abstract

Critically ill patients are a unique group with potentially altered pharmacokinetic and pharmacodynamic characteristics. The provision of optimal care to these patients is best accomplished via an intensivist-led multidisciplinary team. Included on this team should be a pharmacist specifically trained in critical care. The presence of a critical care pharmacist has been documented to not only decrease the cost of drug use in this setting but to improve the quality of care as well. Further investigations should focus on the impact of these interventions on outcomes. These will include pharmacoeconomic outcomes as well as their impact on other parts of the healthcare system in order to avoid cost shifting and improve morbidity and mortality.