Critical Appraisal of Nothapodytes nimmoniana (J. Graham) Mabb. Extraction Methods, Pharmacological Activities, and Future Prospects

Abstract

Nothapodytes nimmoniana (J. Graham) Mabb., commonly known as Narkya, holds immense potential as a medicinal plant, exhibiting a wide array of pharmacological activities. This review provides a comprehensive overview of the methods used for extracting bioactive compounds from different plant parts, along with an exploration of their diverse pharmacological activities. The plant’s significance stems from its high content of camptothecin (CPT), a potent anti-cancer alkaloid. We delve into the plant’s anti-microbial, antioxidant, anti-tumor, anti-helminthic, anti-malarial, and anti-inflammatory properties. Additionally, we highlight the challenges faced by N. nimmoniana (J. Graham) Mabb., due to overexploitation and its endangered status. To address these concerns, the review underscores the importance of sustainable conservation strategies and the implementation of advanced techniques like plant tissue culture and endophyte production for increased CPT production. This holistic analysis not only sheds light on the plant’s multifaceted benefits but also underscores the need for responsible utilization and conservation efforts.