Abstract
A controlled critical test method was used to evaluate the anthelmintic effects of ivermectin (22, 23-dihydroavermectin B1 (MK-933) given as a single intramuscular injection to 20 naturally-parasitized ponies. Dosages tested were 0 (placebo), 200, 300 and 500μg/kg of body weight. In comparison with necropsy data from the 5 placebo-injected controls, ivermectin treatment at 200 μg/kg BW (the lowest dosage) had an antiparasite efficacy of > 98–100% against Onchocerca cervicalis microfilariae, 2nd-and 3rd-instar Gasterophilus intestinalis and G. nasalis, immature and female Habronema muscae, immature and adult Draschia megastoma, Anoplocephalaperfoliata, adult Strongylus vulgaris and S. edentatus, immature and adult small strongyles. Reduced efficacy of varying degrees at 200 μ/kg BW was seen against H. muscae males (88%); Oxyuris equi immature (>97%), male (>34%) and female (>97%) worms. Oxyuris males were completely removed at higher dosages, but female O. equi were inconsistently removed. There were no H. muscae seen at higher dosages. There were no adverse reactions seen due to treatment nor gross abnormalities of the tissue at the injection site.
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