Abstract

Mohammadreza Mohseni1, Mahsa Rastegar Moghaddam Mansouri2, Sivakumar J T Gowder3,4* Author Affiliations 1Lifestyle Gym, Tehran, Iran 2Faculty of Sports Sciences, Hakim Sabzevari University, Sabzevar, Iran 3Bionanotechnology Research Group, Ton Duc Thang University, Ho Chi Minh City, Vietnam 4Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam Received: September 22, 2020 | Published: September 29, 2020 Corresponding author: Sivakumar J T Gowder, Ton Duc Thang University, Ho Chi Minh City, Vietnam DOI: 10.26717/BJSTR.2020.30.005007

Highlights

  • Coronavirus disease 2019 (COVID-19) is the third highly pathogenic coronavirus after SARS-CoV and middle east respiratory syndrome corona virus (MERS-CoV)

  • The S protein or envelope spike glycoprotein of COVID-19 directly latches onto human cells, undergoes structural changes and could fuse to cell membrane and enter into host cells

  • Necroptosis is one kind of cell death that works with receptorinteracting protein kinase 1 (RIPK1) and RIPK3 and linked to endoplasmic reticulum (ER) stress which is activated via tumor necrosis factor receptor 1 (TNFR1) while apoptosis is locked

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Summary

Introduction

Coronavirus disease 2019 (COVID-19) is the third highly pathogenic coronavirus after SARS-CoV and middle east respiratory syndrome corona virus (MERS-CoV). Coronavirus has a positive sense viral RNA genome ranging from 26 to 32 kilobases in length that acts as mRNA and translated into protein in host cell. The S protein or envelope spike glycoprotein of COVID-19 directly latches onto human cells, undergoes structural changes and could fuse to cell membrane and enter into host cells.

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