Abstract
Results of evaluation of the impact of drugs on indicators of clinical laboratory diagnostics as a criterion of safety of therapy are presented. Antiretroviral therapy for HIV infection was chosen as an example. Information from official sources (summary of product characteristics and medicinal product labels) on the potential impact of antiretroviral drugs registered in the Russian Federation on indicators of clinical laboratory diagnostics was analyzed and systematized. Individual INN and antiretroviral regimens recommended by WHO documents and protocols of follow-up and treatment of patients with HIV infection in the Russian Federation with the maximum and minimum potential impact on indicators of clinical laboratory diagnostics were revealed. The research results can be used to develop recommendations for the rational choice, prescription and use of medicines.
Highlights
Results of evaluation of the impact of drugs on indicators of clinical laboratory diagnostics as a criterion of safety of therapy are presented
Antiretroviral therapy for HIV infection was chosen as an example
Information from official sources on the potential impact of antiretroviral drugs registered in the Russian Federation on indicators of clinical laboratory diagnostics was analyzed and systematized
Summary
Results of evaluation of the impact of drugs on indicators of clinical laboratory diagnostics as a criterion of safety of therapy are presented. АЧТВ — активированное частичное тромбопластиновое время; ЛПНП — липопротеины низкой плотности; ЛПВП — липопротеины высокой плотности; АсАТ — аспартатаминотрансфераза; АлАТ — аланинаминорансфераза; КФК — креатининфосфокиназа; ГГТ — гамма-глутамилтрансфераза; ЩФ — щелочная фосфатаза; ЛДГ — лактатдегидрогеназа; ТТГ — тиротропный гормон. Результаты анализа показателей КЛД, потенциально изменяющихся под действием АРВП Результаты анализа влияния классов АРВП на подгруппы показателей КЛД
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