Abstract

Avian sarcoma and leukosis virus (ASLV), diversified into seven phylogenetically relativesubgroups (A, B, C, D, E, J, and K), present as either exogenous or endogenous viruses in domesticchicken. [...]

Highlights

  • Jiří Hejnar 1,*, Anna Koslová 1, Pavel Trefil 2, Jiří Plachý 1, Markéta Reinišová 1, Dana Kučerová 1, Jitka Mucksová 2 and Jiří Kalina 2

  • The ALV-J subgroup enters the cell through a receptor identified as the chicken Na+/H+ exchanger type 1 with twelve predicted transmembrane segments and the prominent extracellular loop 1

  • We recently established a new technique for transgenesis in chicken, which improves the efficiency of gene modification and skips the chimeric G0 stage [3]

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Summary

Introduction

Jiří Hejnar 1,*, Anna Koslová 1, Pavel Trefil 2 , Jiří Plachý 1, Markéta Reinišová 1, Dana Kučerová 1, Jitka Mucksová 2 and Jiří Kalina 2. Institute of Molecular Genetics, Czech Academy of Sciences, Vídeňská 1083, CZ-14220 Prague 4, Czech Republic; anna.lounkova@gmail.com (A.K.); jiri.plachy@img.cas.cz (J.P.); marketa.reinisova@img.cas.cz (M.R.); dana.kucerova@img.cas.cz(D.K.) BIOPHARM, Research Institute of Biopharmacy and Veterinary Drugs, CZ-25449 Jílové u Prahy, Czech Republic; pavel.trefil@bri.cz (P.T.); jitka.mucksova@bri.cz (J.M.); jiri.kalina@bri.cz (J.K.)

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