Abstract
Abstract CRISPR-Cas is a novel tool that may pinpoint the underlying cause of eye diseases. Here, we introduce the different types of CRISPR-Cas systems with an emphasis on type II and present its applications in eye diseases based on
Highlights
Bacterial cells have evolved two well-characterized systems to protect themselves against foreign DNA
CRISPR repeats were first identified in E. coli K12 as identical 29-nucleotide repeat sequences separated by 32-nucleotide nonrepetitive sequences [1]
CRISPR-Cas has been successfully utilized in the study of pigmentation genes like tyrosinase and golden
Summary
Bacterial cells have evolved two well-characterized systems to protect themselves against foreign DNA. One is the restrictionmodification system and the other is the CRISPR-Cas system. Both systems maintain and promote the survival of the bacterial genome. Restriction endonucleases perhaps provide protospacers for CRISPR-array. CRISPR repeats were first identified in E. coli K12 as identical 29-nucleotide repeat sequences separated by 32-nucleotide nonrepetitive sequences [1]. The CRISPR operon is made up of CRISPR array of repeats and spacers along with cas genes encoding CRISPR-associated proteins
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