Abstract
CRISPR-based genome editing tools used for genetic disease treatment mainly include Cas nucleases, base editors (BEs), and prime editors (PEs). High-throughput functional screenings enable accurate dissection of complex proteins, and identification of single nucleotide variants (SNVs) within the same gene, including those that confer sensitivity or resistance to drugs. Efficient delivery of genome editing machinery to target cells or tissues is crucial for successful genome modification either in or outside the body. Viral vectors such as lentivirus (LV), adenovirus (Adv), and adeno-associated virus (AAV) offer complementary advantages, and non-viral delivery provides the advantage of transient editing activity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
