Abstract
During 2013–2014, we collected 1,926 serum samples from humans and 4,583 ticks (Hyalomma asiaticum or Dermacentor nuttalli) in select regions of Mongolia to determine the risk for Crimean-Congo hemorrhagic fever virus (CCHFV) infection among humans in this country. Testing of human serum samples by ELISA demonstrated an overall CCHFV antibody prevalence of 1.4%; Bayankhongor Province had the highest prevalence, 2.63%. We pooled and analyzed tick specimens by real-time reverse transcription PCR; 1 CCHFV-positive H. asiaticum tick pool from Ömnögovi was identified. In phylogenetic analyses, the virus’s partial small segment clustered with CCHFV isolates from Central Asia, and the complete medium segment grouped with CCHFV isolates from Africa, Asia, and the Middle East. This study confirms CCHFV endemicity in Mongolia and provides information on risk for CCHFV infection. Further research is needed to better define the risk for CCHFV disease to improve risk mitigation, diagnostics, and surveillance.
Highlights
During 2013–2014, we collected 1,926 serum samples from humans and 4,583 ticks (Hyalomma asiaticum or Dermacentor nuttalli) in select regions of Mongolia to determine the risk for Crimean-Congo hemorrhagic fever virus (CCHFV) infection among humans in this country
CCHFV Serologic Testing in Humans To assess the overall risk for CCHFV infection in Mongolia, we tested 1,926 serum samples collected from nomadic herders and local residents in select regions of the country by ELISA
To better determine the risk for CCHFV infection among humans in Mongolia, we conducted an assessment that included a CCHFV IgG serosurvey and screening for CCHFV RNA in ticks collected in parallel with the serosurvey
Summary
During 2013–2014, we collected 1,926 serum samples from humans and 4,583 ticks (Hyalomma asiaticum or Dermacentor nuttalli) in select regions of Mongolia to determine the risk for Crimean-Congo hemorrhagic fever virus (CCHFV) infection among humans in this country. No published studies provide evidence of human infection or of virus circulating in tick vectors. Serologic evidence of CCHFV infections in wildlife and livestock suggests the virus circulates in Mongolia and that CCHFV infections are possible for persons exposed to biting ticks or infectious tissues or fluids. We sought to better characterize the risk for CCHFV infection among the population of Mongolia by determining antibody prevalence in humans associated with livestock. Crimean-Congo Hemorrhagic Fever Virus, Mongolia and by surveying ticks collected from the environment and livestock for evidence of CCHFV infection
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
