Abstract
Despite increasing efforts and support for anti-malarial drug R&D, globally anti-malarial drug discovery and development remains largely uncoordinated and fragmented. The current window of opportunity for large scale funding of R&D into malaria is likely to narrow in the coming decade due to a contraction in available resources caused by the current economic difficulties and new priorities (e.g. climate change). It is, therefore, essential that stakeholders are given well-articulated action plans and priorities to guide judgments on where resources can be best targeted.The CRIMALDDI Consortium (a European Union funded initiative) has been set up to develop, through a process of stakeholder and expert consultations, such priorities and recommendations to address them. It is hoped that the recommendations will help to guide the priorities of the European anti-malarial research as well as the wider global discovery agenda in the coming decade.
Highlights
Despite increasing efforts and support for anti-malarial drug R&D, globally anti-malarial drug discovery and development remains largely uncoordinated and fragmented
The RBM Partnership's Global Malaria Action Plan emphasized the need for an R&D agenda [2], which subsequently led to the launch of the MalERA Initiative [3]
Recent concerns in Cambodia about the loss of efficacy of artemisinins underlines the ability of the parasite to respond to new agents [9]. It shows that the global malaria community cannot afford to assume that once it has a highly effective tool this will reduce the need for new drugs with novel mechanisms of action to meet future resistance problems
Summary
Despite increasing efforts and support for anti-malarial drug R&D, globally anti-malarial drug discovery and development remains largely uncoordinated and fragmented. It shows that the global malaria community cannot afford to assume that once it has a highly effective tool (such as ACT) this will reduce the need for new drugs with novel mechanisms of action to meet future (if not yet identified) resistance problems.
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