Abstract

Amidst the current health crisis and social distancing, telemedicine has become an important part of mainstream of healthcare, and building and deploying computational tools to support screening more efficiently is an increasing medical priority. The early identification of cervical cancer precursor lesions by Pap smear test can identify candidates for subsequent treatment. However, one of the main challenges is the accuracy of the conventional method, often subject to high rates of false negative. While machine learning has been highlighted to reduce the limitations of the test, the absence of high-quality curated datasets has prevented strategies development to improve cervical cancer screening. The Center for Recognition and Inspection of Cells (CRIC) platform enables the creation of CRIC Cervix collection, currently with 400 images (1,376 × 1,020 pixels) curated from conventional Pap smears, with manual classification of 11,534 cells. This collection has the potential to advance current efforts in training and testing machine learning algorithms for the automation of tasks as part of the cytopathological analysis in the routine work of laboratories.

Highlights

  • Cervical cancer is one of the most frequently diagnosed neoplasms and one of the main causes of death from cancer in the female population, and constitutes a significant public health problem worldwide[1]

  • The discovery that cervical infection by high oncogenic risk human papillomavirus (HPV) genotypes can progress to cervical cancer has led to the advancement of HPV molecular detection tests to screen for this neoplasm[5]

  • We provided a playground area available at https://playground.database.cric.com.br/ where users may login to their own area to upload and classify their images

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Summary

Introduction

Cervical cancer is one of the most frequently diagnosed neoplasms and one of the main causes of death from cancer in the female population, and constitutes a significant public health problem worldwide[1]. According to the most recent estimate by the World Health Organization (WHO), it is the fourth most incident cancer among women worldwide, with approximately 342,000 deaths in 2020, and is the leading cause of cancer death in 42 countries[2]. Cervical cancer has one of the best prognosis for prevention and cure, reaching almost 100% of cure when diagnosed early with screening methods[3]. The discovery that cervical infection by high oncogenic risk human papillomavirus (HPV) genotypes can progress to cervical cancer has led to the advancement of HPV molecular detection tests to screen for this neoplasm[5]. The Pap test is still essential, since positivity for oncogenic HPV still requires cytological information[6,7] as a follow-up

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