Abstract
Using in-situ hybridization histochemistry we investigated the distribution of CRH receptor 1 (CRH-R1) mRNA in the cortex of C57BL/6 (C57) and DBA/2 (DBA) strains and its regulation after repeated restraint stress. We show that DBA mice have a higher concentration of CRH-R1 mRNA than C57 mice. Repeated restraint stress produced an increase in CRH-R1 mRNA expression of C57 mice, whereas it was uneffective in DBA mice.
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