Abstract
The National Cancer Institute (NCI) clinical cooperative groups have been instrumental over the past 50 years in developing clinical trials and evidence-based clinical trial processes for improvements in patient care. The cooperative groups are undergoing a transformation process to launch, conduct, and publish clinical trials more rapidly. Institutional participation in clinical trials can be made more efficient and include the expansion of relationships with international partners. This paper reviews the current processes that are in use in radiation therapy trials and the importance of maintaining effective credentialing strategies to assure the quality of the outcomes of clinical trials. The paper offers strategies to streamline and harmonize credentialing tools and processes moving forward as the NCI undergoes transformative change in the conduct of clinical trials.
Highlights
The national cooperative group clinical trials system is more than 50 years old
Radiation therapy became incorporated as an important discipline in the clinical cooperative group community
In 1969, the Radiologic Physics Center (RPC) was funded by the National Cancer Institute (NCI) with the mission to assure both the NCI and clinical cooperative system that institutions participating in the clinical trials process deliver comparable and consistent radiation therapy compliant to study objectives
Summary
Edited by: Charles Kunos, Case Western Reserve University and University Hospitals of Cleveland, USA. University of California at San Diego, USA Catheryn Yashar, University of California at San Diego, USA. The National Cancer Institute (NCI) clinical cooperative groups have been instrumental over the past 50 years in developing clinical trials and evidence-based clinical trial processes for improvements in patient care. The cooperative groups are undergoing a transformation process to launch, conduct, and publish clinical trials more rapidly. This paper reviews the current processes that are in use in radiation therapy trials and the importance of maintaining effective credentialing strategies to assure the quality of the outcomes of clinical trials. The paper offers strategies to streamline and harmonize credentialing tools and processes moving forward as the NCI undergoes transformative change in the conduct of clinical trials
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