Creationa and Assessment of Dry Powder Inhalation Formulations of Gamma Oryzanol Based on Chitosan Nanoparticles

Abstract

Gamma oryzanol is an antioxidant and anticancer medication that is taken orally by a traditional method. It comes from plants. Its utility is nonetheless restricted by its erratic absorption and frequent administration. An alternative method that can maintain the release of Gamma Oryzanol in the lungs for several hours was considered: giving the drug via the pulmonary route as nanoparticles. Gamma Oryzanol was coated with chitosan, a biodegradable polymer, and then freeze-dried to create a dry powder inhaler (DPI) with an aerodynamic particle size of 1.54μm. Initial burst release was seen in an in vitro release investigation, which was followed by continuous release up to 97.51% in 24 hours. In vivo research and in vitro release showed further correlation. After a single dosage was administered, the prepared DPI enhanced the Gamma Oryzanol via pulmonary route residence in the lung tissue for more than 24 hours and sustained the Gamma Oryzanol through pulmonary pathway concentration above MIC for more than 12 hours. A decrease in the amount administered in the lungs was also seen in an animal investigation; this will help with tumour treatment.