Abstract
New hydrogel dressings containing the herbal medicinal substance "Alkhydin", obtained from the Kirghiz (Alhagi kirghisorum Schrenk), grown in Kazakhstan, were obtained by radiation irradiation of the initial reaction mixture (IRM). Poly-<br />N-vinylpyrrolidone (PVP) with a molecular weight (MM) of 1 ppm was used to prepare hydrogel dressings as the main gelling polymer for IRM, agar-agar and lowmolecular polyethylene glycol MM = 600 were used as auxiliary substances. The main regularities of the formation of the three-dimensional structure of PVP under conditions of irradiation of IRM are investigated. It is shown that with increasing PVP in IRM, as well as irradiation dose, the yield of gel fraction increases and the degree of swelling decreases. Obviously, these effects are due to an increase in the degree of cross-linking of the polymer network formed. For the obtained hydrogel dressings containing the herbal medicinal substance Alkhydin, cytotoxic effects on the culture of mouse embryonic fibroblasts obtained by primary trypsinization were studied. The results obtained in this case testify to the absence of a cytotoxic effect on the cell culture. In conditions "in vivo" in rats using the model of thermal skin burn, the wound healing effect of hydrogel dressings with "Alkhydin" was studied. It is shown that such bandages show a pronounced wound-healing effect. This is evidenced by a higher rate of reduction in the area of the burn wound treated with a hydrogel dressing compared to the control.
Highlights
The use of hydrogels to replace damaged tissues is the main incentive for their synthesis and detailed investigation
It is shown that such bandages show a pronounced wound-healing effect. This is evidenced by a higher rate of reduction in the area of the burn wound treated with a hydrogel dressing compared to the control
This is evidenced by a higher rate of reduction in the area of the burn wound, treated with wound dressing with Alkhydin, compared to the control
Summary
The use of hydrogels to replace damaged tissues is the main incentive for their synthesis and detailed investigation. Copolymer hydrogels or multipolymer hydrogels make them attractive because they impart a variety of the chemical and physical properties for medical applications by combining the different monomeric units [4,5,6] Natural polymers such as chitin, chitosan, and alginate are used for wound because they offer an important role for the healing process. The radiation process has various advantages, such as easy process control, the possibility of joining hydrogel formation and the sterilization in one technological step, no necessity to add any initiators and crosslinkers which are possibly harmful and difficult to remove They make irradiation the method of choice in the synthesis of hydrogels [8]
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