Abstract
Creation of pharmaceutical compositions with the antifungal, antimicrobial and keratolytic activity
Highlights
National University of Pharmacy SI “Lugansk State Medical University” of the Ministry of Health of Ukraine, Rubizhne*
The microbiological studies of ”Propolis-Derma” medicated products (“Propolis-PNH”, “Propolis-PSC” and “Propolis-PCD”) with the antifungal, antimicrobial and keratolytic activity developed for the treatment of dermatomycoses, pityriasis versicolor, аs well as diseases caused by yeast-like fungi of Candida genus have been carried out
“PropolisPNH”, “Propolis-PSC” and “Propolis-PCD” drugs show the fungicidal and fungistatic action in relation to yeast fungi and the fungicidal action in relation to dermatophytes, molds and dimorphic fungi; they are recommended for use in mycosis of the scalp, skin candidiasis, dermatomycosis of the trunk and extremities
Summary
National University of Pharmacy SI “Lugansk State Medical University” of the Ministry of Health of Ukraine, Rubizhne*. The microbiological studies of ”Propolis-Derma” medicated products (“Propolis-PNH”, “Propolis-PSC” and “Propolis-PCD”) with the antifungal, antimicrobial and keratolytic activity developed for the treatment of dermatomycoses, pityriasis versicolor, аs well as diseases caused by yeast-like fungi of Candida genus have been carried out. It has been determined that the pharmaceutical compositions proposed do not reveal the adverse action and comply with the requirements of the State Pharmacopeia of Ukraine. They can be used to treat mycoses in conditions of high resistance of fungi to traditional antifungal drugs. Under present-day conditions pathogens of fungal diseases or dermatomycoses are pathogenic fungi parasitizing on the human skin and mucous membranes [2, 3]. When choosing the pharmacotherapy of fungal infections the preference should be given to substances and drugs that exhibit a wide range of the therapeutic activity In this respect, the products of beekeeping and their combinations with biologically active substances of natural and synthetic origin, namely the tincture of propolis, dimethylsulphoxide, econazole nitrate, сhlorhexidine digluconate, naftifine hydrochloride, the propolis phenolic hydrophobic drug
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