Abstract
Estimation of endogenous creatinine clearance (Cr. Cl. ) was done in 139 apparently healthy Indian children (94 boys and 45 girls) between 4-12 years age belonging to poor socio economic class. The mean Cr. Cl. was 56.84 ml/min/1.73 M2 (59.54 in boys and 53.12 in girls) which was lower than reported from West (127ml/min/1. 73M2 by Barnett et al). Analysing the data it was noted that Cr. Cl. was influenced by weight and not age. There was statistically significant difference in Cr. Cl. values of children below 10th percentile by weight when compared with those above 10th percentile by I. CM. R. (Indian Council of Medical Research) Standard for weight. Mean Cr.Cl. for girls and boys below 10th percentile were 36.9 and 45.3 ml/min/1. 73M while for those above 25th percentile were 54.5 and 61.8 ml/min/1.73M2 respectively. Low Cr.Cl. in underweight children was due to low urinary creatinine excretion due to poor muscle mass (25.8 mg/dl and 55.6mg/dl in children belonging to 10th and 25th percentile by weight respectively. The serum creatinine levels and urine volume per minute did not differ according to age, sex or weight.
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