Creatinine and eGFR are similarly predictive of outcome of acute coronary syndrome

Abstract

Introduction This study aimed to compare the ability of creatinine and estimated glomerular filtration rate (eGFR) to predict outcome in unselected patients with acute coronary syndrome (ACS). Methods Data on renal function at admission and in-hospital outcome were available for 781 of 1165 consecutive admissions with definite or suspected ACS to two Scottish district general hospitals. The c-statistic was used to compare the ability of serum creatinine and eGFR to predict in-hospital death or major acute coronary event (MACE) defined as recurrent myocardial infarction, recurrent ischaemia requiring percutaneous intervention or death. Results There were no significant differences between the c-statistic for prediction of death (creatinine 0.76 (95% CI 0.68–0.84), eGFR 0.80 (95% CI 0.73–0.87)) or MACE (creatinine 0.63 (95% CI 0.57–0.69), eGFR 0.61 (95% CI 0.55–0.67)). Conclusion Creatinine and eGFR are similarly predictive in stratifying risk of mortality and MACE in ‘real world’ patients with acute coronary syndrome.