Abstract
The interaction of chitosan with cephalosporin (cefazolin and cefotaxime) and aminoglycoside (amikacin and gentamicin) antibiotics was investigated. It was established that the medicinal preparation could be distributed in the polymer matrix in two ways during formation of the film coating. Apart of it was bound rather strongly to the polymer chain, e.g., via complexation. Another part of it was concentrated in the polymer free space (in polymer pores). Astudy of antibiotic release from chitosan film coatings showed that the release rate from the film was determined on one hand by the amount of antibiotic complexed to chitosan and, on the other, to the condition of the polymer matrix. These films could be suitable for treatment of surgical wounds, burns, and slow-healing wounds of various etiology.
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