Abstract
Chronic limb ulcer is one of many dangerous complications of diabetes mellitus. Creating a skin lesion model in rats with diabetes and hyperlipidemia opens the door for testing new treatments in clinical practice. Wistar male rats were induced to have diabetes and dyslipidemia using a high-fat diet for six weeks and low-doses Streptozocin (STZ) injections (35 mg/kg). After that, skin wounds were created by cutting the total skin layer; observation of healing process and histopathological assessment were conducted. The results showed that rats fed with a high-fat diet combined with low-dose STZ injection induced hyperlipidemia and hyperglycemia that remained above 11 mmol/L during the follow-up period. The diabetic and hyperlipidemic rats had longer wound healing time than the normal rats. Thus, this study successfully created an excisional skin wound model on Wistar rats with diabetes and hyperlipidemia which could serve in future testing phases of new wound healing treatments.
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