Creatine supplementation effect on oxidative stress and physical exercise

Abstract

This article explores the role of creatine supplementation in the processes of oxidative stress during exercise. Oxidative stress is the result of an imbalance between the formation and elimination of reactive oxygen species (ROS), which degrade biogenic substances: deoxyribonucleic acid (DNA), proteins, lipids, and can lead to tissue damage. In the course of physical activity, there is a physiological increase in the processes of oxidative stress. Although intense exercise contributes to oxidative damage to muscle fibers, regular physical activity enhances the ability of cells to eliminate excess ROS. Moderateintensity exercise has been shown to increase antioxidant protection. Endogenous antioxidants cannot completely prevent oxidative damage under physiological and pathological conditions (high-intensity and elevated training). The latter can cause endogenous antioxidant imbalance and increase oxidative stress. Scientific studies show the presence of an antioxidant effect in creatine and demonstrate that the use of creatine supplements increases adaptation to physical activity.