Abstract
Previous investigations in our laboratory (1, 2) have shown that the creatinuria observed in whole-body X-irradiated rats is caused by a defect in the ability of skeletal muscle to take up creatine from blood. Such an abnormality could be the result of direct damage to the muscle caused by the incident radiation or could represent an abscopal effect on the muscle mediated by some indirect mechanism other than the adrenal (3). In the present investigation, the direct and indirect action of radiation on creatine uptake by skeletal muscle has been assessed by comparing the ratio of the specific activity of urinary creatine to muscle creatine in X-irradiated and shielded muscle of rats receiving partial-body exposure prior to injection of creatine-l-C14.
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