Abstract
Creatine kinase and C reactive protein as an indicator for tissue damage in the retained placenta in cows
Highlights
C reactive protein (CRP) is a ring shape protein that synthesis and release from the liver with fibrinogen in response to the production of interleukin six released from stimulated macrophages, T lymphocytes and adipocytes by dying or dead cell due to a wide range of inflammatory process either acute or even chronic reaction, due to rheumatic arthritis, pathogenic microorganisms, lethal or sublethal cellular injury [1]
C Reactive Protein (CRP) is a member of patterns recognition receptor (PRR) system that responsible for the detection of necrotic, apoptotic cells as well as pathogenic microorganisms, in which CRP where bind to lysophosphatidylcholine on the cell membrane of dead and dying cells, this lysolecithins were synthesis by hydrolysis of lipids present on the cell membrane by the action of phospholipase that released from affected cells, these complex of CRP with lysolecithins will cause activation 400 kDa complement compound known as C1q that lead to initiation and ignition of the complement system to promote and activate phagocytosis conducted by macrophages to necrotic and apoptotic cells [2]
Gender of fetus The result represented in table 2 showed that there were no significant differences in serum concentrations of CRP and Creatine Kinase (CK) in cows whatever the born calf sex was
Summary
C reactive protein (CRP) is a ring shape protein that synthesis and release from the liver with fibrinogen in response to the production of interleukin six released from stimulated macrophages, T lymphocytes and adipocytes by dying or dead cell due to a wide range of inflammatory process either acute or even chronic reaction, due to rheumatic arthritis, pathogenic microorganisms, lethal or sublethal cellular injury [1]. Creatine kinase (CK) is a crystal shape enzyme synthesis in a wide range of cells especially those of high consuming ATP as a source for energy in muscle, brain, retina, ear, spermatogenesis process and graved placenta [3]. Retention of fetal membranes in cows occurs when the uterus fails to expel the fetus covering membranes after one day of calving, which usually occurs within 4-6 hours after parturition. The occurrence of such case in cows could be affected by many factors; mainly types of parturition (normal or dystocia), sex and size of the fetus, twin’s deliveries, number of previous parturitions, abortion and nutritional status of cows [6]. The retained placenta will be expelled with four to six hours after parturition [7]
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