C-reactive Protein, Glomerular Filtration Rate, and Echocardiographic Parameters in Individuals With Different Cardiovascular Risk Categories

Abstract

Despite the emergence of modern biomarkers, innovative methods of examination and treatment, the problems of cardiovascular risk in clinical medicine are still quite relevant. Widespread cardiovascular risk factors and high mortality from diseases of the circulatory system are observed in all countries of the world, including the Kyrgyz Republic thicknesses, relative LV wall thickness, LV myocardial mass, LV myocardial mass index, r. Aim of the study. To study the clinical and functional values of CRP and its relationship with cardiovascular risk factors in patients with chronic non-communicable diseases. Material and methods. The single-center open study included 290 people with different categories of cardiovascular risk, of which 150 men (51.7%), women - 140 (48.3%). All participants were analyzed hemodynamic parameters, indicators of clinical and biochemical parameters. The excretory function of the kidneys was assessed by the level of serum cystatin C. The glomerular filtration rate (GFR) was calculated according to the method of F. Hoek. The size of the left atrium (LA), the linear dimensions of the left ventricle (LV) were taken into account with an assessment of the structural modification of the myocardium. Depending on the concentration of CRP, two groups were formed: 1A and 1B. Results. In patients with high CRP levels, mean age, body mass index, heart rate, platelet, leukocyte, glucose, and cystatin C blood levels were significantly higher, and mean HDL cholesterol and GFR were significantly lower. Left atrial size, LV end-diastolic size, ventricular septal and posterior wall right ventricular E/A ratio, DT (deceleration time) LV, DT (deceleration time) of the right ventricle were significantly higher in the group of individuals with high levels of blood CRP. In patients with normal (1A) and elevated (1B) levels of CRP in the structure of changes in LV geometry, an eccentric variant of LV hypertrophy was significantly more often detected (74.9% and 66.0%, respectively). The blood CRP concentration was positively associated with the size of the left atrium and LV wall thickness, and negatively with the rate of GFR. Conclusion. In individuals with high and very high cardiovascular risk, elevated CRP levels are associated with more pronounced cardiovascular risk factors. In the group of patients with a high level of CRP, structural modification of the myocardium is represented significantly more often by an eccentric variant of LV hypertrophy.