Abstract
The effect of CRP on lymphocyte activation and proliferation in vitro was estimated on the basis of measurement of3H-thymidine incorporation, analysis of distribution of subsequent cell divisions and analysis of IL-2 receptor expression. Low doses of CRP (less than 3μg/ml) stimulated and high doses (over 5μg/ml) inhibited lymphocyte activation, with little effect on proliferating lymphoblasts. The presence of foetal bovine serum or autologous serum modified CRP action on lymphocytes. The inhibitory effect of CRP on lymphocyte proliferation was similar in cultures stimulated by PHA or by allogeneic cells. On the basis of results obtained, CRP is considered a possible immunomodulator.
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