Abstract
Objective:A comparative analysis of C-reactive protein (CRP) and procalcitonin concentration in blood serum and seminal plasma of healthy men and men with reduced concentration of sperm cells.Methods: 73 fertile men were examined. The experimental group included 36 patients with a reduced fertility; the comparison group (control) included 37 men with normal indicators of ejaculate composition. The concentrations of CRP and procalcitonin were determined by the method of enzyme-linked immunosorbent assay.Results: Differences in level of CRP between blood serum and seminal plasma in experimental and control groups occurred to be statistically significant in both groups. There was no correlation between these parameters. The concentration of procalcitonin was almost ten times higher in the seminal plasma than in the blood serum. In the experimen‑ tal group, it was significantly higher in ejaculate than in the comparison group. The concentration of CRP and procalcitonin did not correlate neither with the ejaculate volume nor with concentration or amount of sperm cells in it.Conclusions: The levels of CRP and procalcitonin in seminal plasma can indicate the fertility status of the ejaculate.
Highlights
Differences in level of C-reactive protein (CRP) between blood serum and seminal plasma in experimental and control groups occurred to be statistically significant in both groups
Association of salivary C-reactive protein with the obesity measures and markers in children
Summary
Цель: сравнительный анализ содержания С-реактивного белка (СРБ) и прокальцитонина (ПКТ) в сыворотке крови и се‐ менной плазме здоровых мужчин и мужчин со снижением концентрации сперматозоидов. Основная группа – человек со сниженной фертильностью спермы, груп‐ па сравнения (контроль) – мужчин с нормальными показателями состава эякулята. Различия в уровнях СРБ между сывороткой кро‐ ви и семенной плазмой в основной группе и контроле оказались статистически значимы в обеих группах. В семенной плазме содержание ПКТ было почти в десять раз больше, чем в сыворотке крови. Концентрация СРБ и ПКТ в семенной плазме не коррелировала ни с объемом эякулята, ни с концентрацией или количеством в нем сперма‐ тозоидов. Уровни СРБ и ПКТ в семенной плазме могут свидетельствовать состоянии фертильности эякулята. С-реактивный белок и прокальцитонин биологических жидкостей у мужчин с нормальной и сниженной фертильностью. Vagner Perm State Medical University, Perm, Russia; 2 Ltd Company “MedGarant”, Perm, Russia; 3 Federal Scientific Center for Medical and Preventive Technologies for Public Health Risk Management, Perm, Russia
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