Abstract
Atrial fibrillation (AF) represents the most frequent sustained arrhythmia encountered in clinical practice [ [1] Jahangir A. Munger T.M. Packer D.L. Crijns H.J.G.M. Atrial fibrillation. in: Podrid P.J. Kowey P.R. Cardiac arrhythmia: mechanisms, diagnosis, and management. 2nd ed. Lippincott Williams & Wilkins, Philadelphia, PA2001: 457-499 Google Scholar ]. Structural and electrophysiological remodeling is being widely recognized as a critical process in the pathophysiology of this disorder. Although the exact underlying molecular mechanism(s) remain unknown, calcium overload seems to contribute considerably to these changes [ [1] Jahangir A. Munger T.M. Packer D.L. Crijns H.J.G.M. Atrial fibrillation. in: Podrid P.J. Kowey P.R. Cardiac arrhythmia: mechanisms, diagnosis, and management. 2nd ed. Lippincott Williams & Wilkins, Philadelphia, PA2001: 457-499 Google Scholar ].
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