Abstract
Aims. To investigate the association of C-reactive protein (CRP) and gamma glutamyltransferase (GGT) concentrations with newly diagnosed diabetes defined by either glucose or HbA1c criteria in Chinese adults. Methods. A population-based cross-sectional study was conducted in 2006. Data from 1167 men and 1607 women aged 35–74 years were analyzed. Diabetes was defined according to either glucose or HbA1c criteria alone. Results. Compared with nondiabetes, multivariate-adjusted OR (95%CI) was 1.13 (0.90,1.42) in men and 1.21 (1.00,1.45) in women for CRP and 1.42 (1.18,1.72) and 1.57 (1.31,1.87) for GGT, respectively. Neither CRP nor GGT was associated with the presence of diabetes defined by the HbA1c criterion. Conclusions. The effect of elevated CRP on diabetes defined by the glucose criterion was mediated through obesity, but elevated GGT was an independent risk factor for diabetes in this Chinese population. None of the two was, however, associated with the elevated HbA1c concentrations.
Highlights
A new large Chinese national survey [1] is in consistent with previous report from China [2] showing that type 2 diabetes has become a seriously public health threat in China
The prevalence of an Fatty Liver Index (FLI) of ≥60 is 25.5% in men and 9.6% in women in our present study, and elevated serum gamma glutamyltransferase (GGT) levels was associated with diabetes in both low (FLI
Diabetes defined by the haemoglobin A1c (HbA1c) criterion was associated with none of the two
Summary
A new large Chinese national survey [1] is in consistent with previous report from China [2] showing that type 2 diabetes has become a seriously public health threat in China. The studies suggest that China is taking over India and becoming the epicenter of diabetes in the world. In these previous studies, type 2 diabetes has been defined according to fasting (FPG) and/or 2-hour plasma glucose criteria after ingesting 75 g oral glucose load (OGTT) [3]. Several prospective studies had shown that serum CRP accelerate or increase the development of diabetes [5,6,7,8,9], in women [8, 9]. There is increasing evidence showing that liver enzymes, such as gammaglutamyltransferase (GGT), used as a marker of alcohol consumption or liver disease, show a dose-response relation with incident diabetes even within its normal range [10] and may predict the development of diabetes in both genders independent of traditionally risk factors [11, 12]
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