Abstract
Cre-ating Ways to Serotonin
Highlights
Almost 50 years ago Dahlström and Fuxe discovered serotonergic neurons in the brainstem
For a cell type-selective manipulation, a “Cre driver mouse” is mated with another that has a gene with recognition sites for Cre
Inducible Cre activity, where we can turn on the Cre recombinase at defined ages of the mouse, is better
Summary
Almost 50 years ago Dahlström and Fuxe discovered serotonergic neurons in the brainstem. A commentary on Inducible gene manipulations in serotonergic neurons. Studying circuitry with genetics often involves putting foreign proteins, e.g. Cre (cyclization recombination) site-specific DNA recombinase from bacteriophage P1, in specific cell types (Sauer, 2002; Dymecki and Kim, 2007; Gong et al, 2007).
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