Abstract
A craquelure structure of protein film as indicator of macromolecule state is discussing. Craquelure is a network of fine cracks or crackles on the surface of a painting, caused chiefly by shrinkage of paint film or varnish. The actions of laser radiation in the red and green spectral region on the protein film craquelure structure by the example of albumin are considering. It is experimentally shown that after drying the protein layer a craquelure pattern (variety of cracks in the layer) is formed with the parameters strongly modified by the laser action and depending on the wavelength of radiation and the time (energy density) of exposure.
Highlights
One of the main paradigms of medicine is that the pathologic organism status is reflected in the fluids that wash the cells of the body [1]
Craquelure is a network of fine cracks or crackles on the surface of a painting, caused by shrinkage of paint film or varnish
It is experimentally shown that after drying the protein layer a craquelure pattern is formed with the parameters strongly modified by the laser action and depending on the wavelength of radiation and the time of exposure
Summary
One of the main paradigms of medicine is that the pathologic organism status is reflected in the fluids that wash the cells of the body [1]. Solely the chemical analysis does not provide sufficient information, since it is unable to reveal the conformation modifications of the biological protein macromolecules. The conformation modifications of the protein molecules can manifest themselves before the chemical changes of the blood (urine) composition, or the clinical symptoms of the disease. It was found that the method of film crystallograms is capable of detecting the result of the laser radiation action on a biological fluid [6,7,8,9], namely, the size reduction of the structure elements consisting of macromolecules is recorded (the phenomenon of laser-induced nanoclusterization)
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