Abstract

✓ In 25 Egyptian patients 2 to 18 years of age, craniosynostosis was studied clinically, radiologically, and biochemically. Oxycephaly was the most common manifestation, but single suture synostosis occurred occasionally. Increased intracranial pressure was marked (76%), clinically, radiologically, and at operation. Biochemical changes in the form of increased alpha-1 globulin and alpha lipoproteins, and reversed beta/alpha ratio of lipoproteins, pointed to a mesenchymal defect. Linear craniectomy proved satisfactory in many cases. Deroofing of the optic foramina and orbital decompression did not improve results. The symmetrical limitation of skull growth in oxycephaly resulted in late presentation of the case for treatment. Development of more widespread pediatric care in the United Arab Republic is needed for earlier recognition.

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