Craniospinal Irradiation in Hematological Malignancies: Can the Helical Tomotherapy Become a Standard?

Abstract

According to preliminary clinical experience, craniospinal irradiation (CSI) may be considered as a treatment option in patients with recurrent leukemia involving the central nervous system (CNS). Field matching poses challenges as it leads to a risk of underdosage or overdosage in the junctional area. We investigated the feasibility of CSI using helical tomotherapy (HT), compared the dosimetric and clinical results with patients treated by the 3D conformal technique (3D-CRT) and the intensity-modulated radiation therapy (IMRT).