Abstract
Abstract Cranberry juice, given in maximal tolerable amounts to normal subjects, increases the acidity of the urine slightly and increases the hippuric acid content of the urine by several grams a day. Hippuric acid, in concentrations of 0.02 – 0.04 M, is bacteriostatic at pH 5.0 for the common pathogens of the urinary tract, and its activity decreases about fivefold as the pH is raised to 5.6. Only occasionally does cranberry juice contribute enough hippuric acid to the urine to achieve concentrations which are bacteriostatic at pH 5.O. Hippuric acid, in doses of 12 to 14 Gm. per day, usually lowers the pH of the urine to 5.2 or less, and is excreted in sufficient concentration to induce inhibition of bacterial growth in urine at this pH. The data suggest that the use of hippuric acid as a urinary antiseptic deserves further study.
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