Abstract
The catabolite repressor-activator (Cra) protein controls the direction of carbon flux through metabolic pathways in enteric bacteria. Cra binds to the control regions of target genes and exerts a negative effect on the expression of genes encoding glycolytic and Entner-Duodoroff enzymes, while exerting a positive effect on genes encoding Krebs cycle, glyoxylate shunt and gluconeogenic enzymes. Cra mediates cylic AMP-independent catabolite repression of positively Cra-regulated genes and catabolite activation of negatively Cra-controlled genes.
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