Abstract

As an extension on previous work involving reactions of tertiary enamides with epoxides (Org. Lett. 2008, 10, 2461), the authors now describe the chromium-catalyzed intramolecular nucleophilic addition of tertiary enamides to ketones. The resulting 1H-pyrrol-2(3H)-one ­derivatives bearing a hydroxylated quaternary carbon center were obtained in good yield and with excellent enantioselectivity.

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