Abstract

It is very important to differentiate whether a medullary carcinoma is hereditary or sporadic when determining the treatment strategy preoperatively. If hereditary, it is either multiple endocrine neoplasia type 2 (MEN 2) or familial medullary thyroid carcinoma (FMTC), which is inherited as autosomal dominants. MEN 2A manifests medullary thyroid carcinoma, pheochromocytoma, and parathyroid hyperplasia, and MEN 2B is associated with submucosal neuroma of the tongue and/or lips, hyperextension of the extremities, marfanoid habitus, intestinal ganglioneuromatosis, and thickened corneal nerves, in addition to medullary thyroid carcinoma and pheochromocytoma. FMTC hereditarily develops only as medullary carcinoma. The utility of mutation analysis of the RET gene, which is the responsible gene for MEN 2 and FMTC, is investigated based on the literature

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.