Abstract
912 CPG ISLAND HYPERMETHYLATION OF CELL-FREE SERUM DNA INDICATES WORSE OUTCOME IN PATIENTS WITH BLADDER CANCER Patrick J Bastian*, Jorg Ellinger, Nadja El Kassem, Lukas C Heukamp, Swapna Matthews, Figen Cubukluoz, Philip Kahl, Frank Perabo, Alexander von Rucker, Stefan C Muller. Munich, Germany, and Bonn, Germany. INTRODUCTION AND OBJECTIVE: CpG island (CGI) hypermethylation is a frequent event in bladder carcinogenesis and progression. Our study was designed to investigate the diagnostic and prognostic value of CGI hypermethylation in cell-free serum DNA of bladder cancer (BCA) patients. METHODS: The study cohort consisted of 45 patients with
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