CP-092 Estimated rate of therapeutic failure with palivizumab in the prophylaxis of respiratory syncytial virus

Abstract

Background There is doubt about the criteria for selection of patients eligible to receive palivizumab prophylaxis for respiratory syncytial virus (RSV) and the potential therapeutic failures. Purpose To estimate the rate of therapeutic failure with palivizumab and drug use profile in the study centre. Material and methods Observational, retrospective study. Patients who received palivizumab in 3 seasons (2006–2009) were selected and medical records were reviewed. Variables: Dependent: Rate of therapeutic failure with palivizumab. Independent: Profile of drug use in the study centre. Results Data were obtained from 104 patients: 15/104 were children In 100% of patients, palivizumab was prescribed according to the recommended dosage, and the number of doses prescribed was correct in 99% of cases. 81.7% of patients received all prescribed doses. Other risk factors analysed: 66/104 were male. 13/104 had a chronological age 40/99 had low birth weight (1,500–2,500 g), 45/99 very low birth weight ( Breastfeeding was continued for at least 2 months in 42/93 patients. The rate of therapeutic failure with palivizumab was 3.8%, of the total 104 patients receiving prophylaxis with palivizumab, 4 required hospitalisation for RSV infection. Conclusion The drug use profile in the study centre matched the licensed indications in the SmPC. A protocol that allows an annual review of the criteria for selecting patients for treatment with palivizumab was developed. The rate of therapeutic failure in our study context was very low, so the drug can be considered effective. References and/or Acknowledgements No conflict of interest.