Abstract
Khan AA, Brahim JS, Rowan JS, Dionne RA. In vivo selectivity of a selective cyclooxygenase 2 inhibitor in the oral surgery model. Clin Pharmacol Ther 2002;72:44–9.Prostanoids formed by cyclo-oxygenase inhibitors have an important role in treating pain and inflammation. It is thought that COX-1 is constitutively expressed, whereas COX-2 is induced during inflammation. This study examined the in vivo selectivity of celecoxib, a COX-2 inhibitor, and evaluated whether estimates of selectivity that are based on in vitro and ex vivo analyses are reliable indicators of in vivo selectivity.
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