Abstract

Cowpox virus infection from pet rat

Highlights

  • Poxviruses are the largest double-stranded DNA viruses which replicate in the cytoplasm of host cells

  • Tularemia was the first suspicion in our young patient with oculo-cutaneous lesions combined with lymphadenopathy

  • Tularemia is caused by gram-negative coccobacillus Francisella tularensis and re-emerged in Germany in 2004

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Summary

INTRODUCTION

Poxviruses are the largest double-stranded DNA viruses which replicate in the cytoplasm of host cells. The human-pathogeneic poxviruses belong to several genera: orthopoxvirus, parapoxvirus, yatapoxvirus, camelpox virus, molluscipoxvirus, etc. Cowpox virus belongs to genera orthopoxvirus - a heterogeneous group of viruses that infect a broad spectrum of wild rodents and domestic animals, but seem to be restricted to the Old World [2,3]. Human cowpox is a relatively rare zoonotic infection. Human cowpox can be acquired by implantation of a virus into injured skin after contact with infected animals, mostly cats or rats. Cowpox remains a localized skin disease with or without local lymphadenopathy. The lesions start as erythematous macules developing into papules and seropapules, followed by ulcerated plaques with eschar formation.

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