Abstract
Few studies have focused on clinical courses or viral loads in young asymptomatic or mild patients with COVID-19 infection. We sought to better understand the clinical course and association between viral load and prevalence of pneumonia in young COVID-19 patients with asymptomatic or mild disease severity. In this retrospective study, 106 COVID-19 young patients with asymptomatic or mild disease severity were analyzed for clinical characteristics, clinical course, prevalence of radiologically proven pneumonia and viral load. The cut-off value of viral load for presence of pneumonia was also investigated. The mean age was 28.0±9.3 years. Eleven patients (10.4%) experienced viral remission within one week of diagnosis, but one (0.9%) transferred to the hospital due to aggravation of pneumonia. Patients with pneumonia had significantly higher viral load than those without, and the cut-off value of the Ct value for presence of pneumonia were 31.38. The patients with pneumonia had significantly slower recovery times than those without. Diarrhea was significantly more common in patients with pneumonia than patients without pneumonia. In conclusion, most young asymptomatic and mildly symptomatic patients showed stable clinical course. There were significant differences in viral load and recovery times between patients with and without pneumonia.
Highlights
IntroductionAccording to the literature, 80% of COVID19-infected patients have mild symptoms [2,3,4,5]
The present study showed the clinical course including viral load and association between viral load and prevalence of pneumonia of young COVID-19 patients with asymptomatic or mild disease severity managed in an out-of-hospital community treatment centers (CTCs)
Pneumonia was detected in 45.3% of patients during follow up and all achieved virologic remission and were discharged after viral clearance
Summary
According to the literature, 80% of COVID19-infected patients have mild symptoms [2,3,4,5]. Because of the large number of new infections from patients traveling from overseas with asymptomatic or mild disease, the government’s focus was on thoroughly monitoring and quarantining people entering the country. A policy was established to quarantine all COVID-19 infected patients who traveled from abroad with asymptomatic or mild disease not requiring oxygen therapy according to certain disease severity criteria to out-of-hospital community treatment centers (CTCs). Similar policies may be required in other countries to accommodate the growing number of COVID-19 patients, regardless of whether the infections developed abroad or domestically
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