Abstract
The COVID-19 pandemic is a worldwide, critical public health challenge and is considered one of the most communicable diseases that the world had faced so far. Response and symptoms associated with COVID-19 vary between the different cases recorded, but it is amply described that symptoms become more aggressive in subjects with a weaker immune system. This includes older subjects, patients with chronic diseases, patients with immunosuppression treatment, and pregnant women. Pregnant women are receiving more attention not only because of their altered physiological and immunological function but also for the potential risk of viral vertical transmission to the fetus or infant. However, very limited data about the impact of maternal infection during pregnancy, such as the possibility of vertical transmission in utero, during birth, or via breastfeeding, is available. Moreover, the impact of infection on the newborn in the short and long term remains poorly understood. Therefore, it is vital to collect and analyze data from pregnant women infected with COVID-19 to understand the viral pathophysiology during pregnancy and its effects on the offspring. In this article, we review the current knowledge about pre-and post-natal COVID-19 infection, and we discuss whether vertical transmission takes place in pregnant women infected with the virus and what are the current recommendations that pregnant women should follow in order to be protected from the virus.
Highlights
Pregnancy is an important and “formative period” governed by series of interconnected molecular and cellular mechanisms aimed to promote maternal homeostasis and maintain an optimal fetal-placental interaction while supporting fetal growth [1,2]
Based on data from the Mexican National Registry of Coronavirus [32], the comparison of COVID-19related outcomes between 5183 pregnant and 5183 non-pregnant women with COVID-19 demonstrated that the percentage of death, pneumonia, and intensive care units (ICU) admission were higher in pregnant women [32], suggesting that pregnancy significantly increases the risk of severe COVID-19 infections [33]
This study suggested that the reduced transplacental transfer of antiSARS-CoV-2 antibodies may predispose the neonates to COVID-19 infection
Summary
Pregnancy is an important and “formative period” governed by series of interconnected molecular and cellular mechanisms aimed to promote maternal homeostasis and maintain an optimal fetal-placental interaction while supporting fetal growth [1,2]. Many factors/events can disrupt this balance and lead to adverse pregnancy outcomes [3,4,5], which may result in failing the pregnancy and in few cases of maternal death [3,4] As per the UNICEF (United Nation United Nations International Children’s Emergency Fund), one pregnant woman or newborn dies every 11 s worldwide [6]. This great risk on pregnant women and babies’ health increases dramatically during pandemics [7].
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