Abstract
Although the etiopathogenesis of infections has been largely illuminated by technical and scientific developments in the past century; many issues are still not clear today. The word “there is no disease, there is a patient” is stil valid today. Because the immune response of the host is as important as the virulence of the pathogen in infections and disease course can vary a lot according to the person. Cytokine Storm is seen exactly in a group of diseases where the host response is very prominent. For this reason, Cytokine Storm Syndrome (CSS) is mostly mentioned. CSS emerging due to different inflammatory etiologies; it is an overwhelming systemic inflammation, hemodynamic imbalance, multiple organ failure, and potentially leading to death. After being first seen in Influenza in 2003 as a viral agent, CSS was seen in SARS-Cov, MERS-CoV and SARS-CoV2, which were found to be the las thuman disease from the Corona viridea family.The novel coronavirus SARS-CoV2 causes COVID-19, a pandemic threatening millions. Uncontrolled production of pro-inflammatory mediators contributes to, acut respiratory distress syndrome (ARDS) and cytokine storm syndrome in COVID-19.
Highlights
The etiopathogenesis of infections has been largely illuminated by technical and scientific developments in the past century; many issues are still not clear today
Bu dergide yayınlanan bütün makaleler Creative Commons 4.0 Uluslararası Lisansı (CC-BY) ile lisanslanmıştır. © Copyright Forbes Journal of Medicine. This journal published by Logos Medical Publishing
Bilindiği gibi bazı sistemik otoimmun veya enflamatuar hastalıklarda, immun yanıtın kontrolsüz bir şekilde tetiklenmesi sonucu sınırlandırılamayan doğuştan immun sistem yanıtı sonrası; hücre ve doku hasarı ile açığa çıkan nükleer antijenlerin uyarısı ve proenflamatuar sitokin ekspresyonuyla adaptif immun yanıt aktive olarak, enfeksiyonun başlangıcından 7-10 gün sonra “ikinci dalga” şeklinde yeni bir enflamasyon tablosu ortaya çıkmaktadır
Summary
The etiopathogenesis of infections has been largely illuminated by technical and scientific developments in the past century; many issues are still not clear today. Daha geç dönemde ise enfekte hücreler ölürken, ortama saldıkları virüs parçacıklarıyla beraber hücre içi komponentler; PRRs aracılığıyla hem doğal immun mekanizmaları harekete geçirdiği gibi hem de IL1β, IL-6, TNF-α gibi proenflamatuar sitokinleri de salgılatarak edinilmiş immun mekanizmaları da devreye sokmaktadır.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
