Abstract
There are limited proven therapeutic options for the prevention and treatment of COVID-19. We underwent an observational study with the aim of measure plasma vitamin C levels in a population of critically ill COVID-19 adult patients who met ARDS criteria according to the Berlin definition. This epidemiological study brings to light that up to 82% had low Vitamin C values. Notwithstanding the limitation that this is a single-center study, it nevertheless shows an important issue. Given the potential role of vitamin C in sepsis and ARDS, there is gathering interest of whether supplementation could be beneficial in COVID-19.
Highlights
There are limited proven therapeutic options for the prevention and treatment of COVID-19
Given the potential role of vitamin C in sepsis and Acute Respiratory Distress Syndrome (ARDS), there is gathering interest of whether supplementation could be beneficial in COVD-19 [1, 2]
First of all, we have to know if the incidence of vitamin C deficiency is high
Summary
There are limited proven therapeutic options for the prevention and treatment of COVID-19. We underwent an observational study with the aim of measure plasma vitamin C levels in a population of critically ill COVID-19 adult patients who met ARDS criteria according to the Berlin definition [3]. The patients were admitted to hospital a median 10 days after onset of symptoms and the last intake was the day before hospital admission. Vitamin C levels were measured within the first 24 h of ICU admission. Age (median, min–max, years) Male (n, %) SOFA score (median, min–max, points) Intubation (n, %) Prone position (n, % respect of intubation) VV-ECMO (n, %) VA-ECMO (n, %) Noradrenaline (n, %) Dobutamine (n, %) CKD (n, %) AKI (n, %) CRRT (n, %) IRR (n, %) Bacterial superinfection (n, %) ICU-LOS (median, min–max, days) HOSP-LOS (median, min–max, days) Mortality (n, %).
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