Abstract
Scientific information on the impact of the new coronavirus (SARS-CoV-2) on the health of pregnant women, fetuses and newborns is considered of limited confidence, lacking good-quality evidence, and drawing biased conclusions. As a matter of fact, the initial impressions that the evolution of COVID-19 was no different between pregnant and non-pregnant women, and that SARS-CoV-2 was not vertically transmitted, are confronted by the documentation of worsening of the disease during pregnancy, poor obstetric outcomes, and the possibility of vertical transmission. The present article aims to compile the data available on the association of COVID-19 and reproductive events, from conception to birth.
Highlights
In the last 8 months, the world has been experiencing a pandemic caused by the new coronavirus (SARS-CoV-2)
It is a fact that scientific information on the impact of SARSCoV-2 on the health of pregnant women, fetuses and newborns is considered of limited confidence, lacking good-quality evidence, and drawing biased conclusions
As a precaution, pregnancy and the puerperium are considered high-risk situations for severe illness from COVID-19.37,38 In June 2020, a systematic review[39] of 755 pregnant women presenting with COVID-19 provided only poor-quality evidence, and the authors could not rule out potential worsening of the clinical conditions of pregnant women infected with severe acute respiratory syndrome (SARS)-CoV-2, or whether the infection is associated with comorbidities or not
Summary
In the last 8 months, the world has been experiencing a pandemic caused by the new coronavirus (SARS-CoV-2). As a matter of fact, the initial impressions that the evolution of COVID-19 was no different between pregnant and non-pregnant women,[4,5,6] and that SARS-CoV-2 was not vertically transmitted,[4,7,8] are confronted by the documentation of worsening of the disease during pregnancy, poor obstetric outcomes,[9,10,11,12,13,14] and the possibility of vertical transmission.[15,16,17,18,19,20]. In June 2020, a systematic review[39] of 755 pregnant women presenting with COVID-19 provided only poor-quality evidence, and the authors could not rule out potential worsening of the clinical conditions of pregnant women infected with SARS-CoV-2, or whether the infection is associated with comorbidities or not.
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