COVID-19'U ANLAMAK: SİTOKİN ETKİSİNİN İMMÜNOPATOJENİK MEKANİZMALARI

Abstract

Cytokine release syndrome (CRS) or cytokine storm is
 as a result of the excess production of pro-inflammatory
 cytokines which is due to the disproportionate response
 of the immune system which can be instigated by
 SARS-CoV-2. COVID-19 which is caused by SARSCoV-
 2 has a correlation with cytokines. SARSCoV-
 2 instigates the production of IL-1 by ubiquitous
 macrophages and mast cells. IL-1 tends to influence
 the production of IL-6 and TNF-α. The progression
 of COVID-19 severity influences the level of certain
 cytokines such as IL-6. IL-6 is the cytokine chiefly
 responsible for the occurrence of CRS. CRS is the
 cause of COVID-19-related complications and the
 main cause of COVID-19-related deaths. Despite the
 data reported in the literature so far, the relationship
 between SARS-CoV-2 and cytokines has not been fully
 elucidated. The aim of the present review is to examine
 the relationship in question. Targeting cytokines during
 COVID-19 treatment has the potential to increase
 patient survival and reduce COVID-19-related deaths.
 It is concluded that focusing on the mechanisms of
 cytokine release and the effects of released cytokines,
 especially examining the effects on T lymphocytes
 and IFN-γ production in COVID-19 disease, may help
 reduce the lethal effects of the disease.