COVID-19 exposure during pregnancy and low birth weight in community development blocks, Purba Bardhaman: A retrospective cohort study.

Abstract

COVID-19 exposure during pregnancy is hypothesized to affect the birth weight of the children. Community based findings on such hypothesis are scarce in West Bengal. This study was conducted with the objective to determine the relationship between low birth weight (LBW) and maternal exposure to COVID-19. In this retrospective cohort study, mothers of children, who were born between February 2020 and October 2021 and who were registered in the subcenters of Purba Barddhaman district, West Bengal, were selected as study population. Mothers who were diagnosed as COVID-19 positive during the antenatal period were considered as 'Pregnancy with COVID' and others were considered as 'Pregnancy without COVID'. The minimum required sample size using Fleiss formula were 119 and 476, respectively, whose were selected through multi-stage random sampling. A schedule was used to collect data through review of relevant records of antenatal registers of sub-centers of selected individuals. The association was checked through multivariate logistic regression model where P < 0.05 was considered statistically significant. Incidence of LBW in COVID pregnancy, Non-COVID Pregnancy group were 30.3% and 18.7%, respectively. COVID positivity during pregnancy shows relative risk of 1.62 and attributable risk of 38.28% for LBW baby as pregnancy outcome. Multivariate analysis reveals that LBW babies are significantly associated with COVID status during pregnancy (AOR 2.18, 1.3-3.63) after adjusting for anemia in pregnancy, incomplete antenatal visits, mothers age ≥30 years, parity and periods of gestation. The study concludes that COVID positivity during pregnancy significantly increases the risk of LBW as pregnancy outcome.