Abstract

Interventions implemented amidst ongoing infectious disease outbreaks can act as natural experiments that help to disentangle how pathogens spread and diseases manifest. The most well known example is John Snow's seminal cholera study from mid-19th century London. Suspecting that recurring cholera outbreaks were resulting from drinking water contaminated with sewage, Snow recognised the relocation of water intake pipes to a source upstream from city effluent as an opportunity to test, and ultimately confirm, his hypothesis.

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