COVID-19 Beyond the Lungs: Neuropsychiatric Symptoms and EEG Correlations

Abstract

Abstract: COVID-19, previously considered a mere respiratory illness affecting predominantly the adult age, is today acknowledged as the cause of a wide spectrum of multisystemic signs and symptoms, ranging from mild to severe degrees, including neurological manifestations. Even if less frequently than adults, pediatric patients may also develop severe COVID-19 and present with peculiar clinical pictures, including multi-system inflammatory syndrome (MIS-C) and neuropsychiatric manifestations. Mounting evidence is available on the potential pathogenic mechanisms underpinning the nervous system involvement and on the Post-COVID19 sequelae. However, little is known about EEG changes that may come along with them, particularly in the pediatric age. Herein, we briefly overview the neuropsychiatric COVID-19-related features in pediatric patients and the reported potential EEG correlates. Further research may help unravel new insights and provide new biomarkers regarding diagnosis, prognosis, and treatment options for post-- COVID-19 neuro-cognitive disorders.